⮝ Full datasets listing
PXD082250
PXD082250 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Intestinal β-galactosidase acts as a regulator of sepsis progression |
| Description | This project investigates the role of intestinal β-galactosidase in sepsis using 16S rRNA sequencing, metabolomic, and proteomic analyses. Septic patients showed reduced intestinal β-galactosidase activity associated with depletion of putative β-galactosidase-producing bacteria, including Blautia, Faecalibacterium, and Ruminococcus. Metabolomic profiling identified hesperetin as a key microbiota-associated metabolite, and proteomic analysis identified CDK13 as a critical downstream target regulating NLRP3 inflammasome priming and macrophage pyroptosis. Restoration of intestinal β-galactosidase promoted dietary hesperetin liberation and improved survival in septic mice. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-05 |
| AnnouncementXML | Submission_2026-08-06_00:51:27.532.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kaixin Ding |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-06 00:51:02 | ID requested | |
| ⏵ 1 | 2026-08-06 00:51:28 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Sepsis, Gut microbiota, Hesperetin, CDK13, Macrophage pyroptosis |
Contact List
| Shenhai Gong | |
|---|---|
| contact affiliation | Southern Medical University |
| contact email | gsh0526@smu.edu.cn |
| lab head | |
| Kaixin Ding | |
| contact affiliation | Southern Medical University |
| contact email | dingkaixin97@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
