PXD082246

PXD082246 is an original dataset announced via ProteomeXchange.

Title	Clostridium butyricum improves lenvatinib plus anti-PD-1 efficacy in hepatocellular carcinoma
Description	This dataset contains two mass spectrometry-based proteomic experiments investigating the effects of indole-3-propionic acid on hepatocellular carcinoma and macrophage lipid metabolism. The first experiment includes liver tumor tissues from orthotopic hepatocellular carcinoma-bearing mice treated with lenvatinib plus anti-PD-1 therapy with or without indole-3-propionic acid supplementation. The second experiment includes mouse bone marrow-derived macrophages treated with or without indole-3-propionic acid in vitro. These analyses were performed to identify IPA-associated changes in protein expression and signaling pathways related to lipid droplet metabolism, lipophagy, autophagy, macrophage polarization, and antitumor immune responses. The deposited files include raw mass spectrometry data, protein and peptide identification results, quantitative expression matrices, experimental metadata, and data-processing outputs.
HostingRepository	iProX
AnnounceDate	2026-08-05
AnnouncementXML	Submission_2026-08-06_00:38:09.359.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yinan Li
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-08-06 00:37:47	ID requested
⏵ 1	2026-08-06 00:38:09	announced

Dataset with its publication pending

submitter keyword: indole-3-propionic, tumor-associated macrophages

Maolin Yan
contact affiliation	Fujian Medical University
contact email	yanmaolin74@163.com
lab head
Yinan Li
contact affiliation	Fujian Medical University
contact email	leeynn111@126.com
dataset submitter

iProX dataset URI