PXD082176 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Striatal Synaptoproteomics of HSF1 Conditional Knock Out in the Adult Mouse Brain |
| Description | This project examined the effects of the conditional knockout of the transcription factor HSF1 in striatal neurons on the proteome of synapses. HSF1 is a prolific stress-responsive transcription factor, but it has been indicated in regulating synapse stability under physiological conditions in the mammalian CNS. Here, we excised the HSF1 gee from striatal neurons and examined the effects on protein levels. We find that the loss of HSF1 specifically enhances the expression of proteins involved in synapse organization and cell-cell adhesion, while depleting mitochondrial proteins. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-20 |
| AnnouncementXML | Submission_2026-08-20_04:08:25.708.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nicholas Rozema |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-08-04 18:12:06 | ID requested | |
| ⏵ 1 | 2026-08-20 04:08:26 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: synaptosomes, HSF1, brain,striatum |
Contact List
| Rocio Gomez-Pastor |
|---|
| contact affiliation | Department of Neuroscience, University of Minnesota, Medical School |
| contact email | rgomezpa@umn.edu |
| lab head | |
| Nicholas Rozema |
|---|
| contact affiliation | Department of Neuroscience, University of Minnesota, Medical School |
| contact email | nicholas.rozema@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD082176 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD082176
- Label: PRIDE project
- Name: Striatal Synaptoproteomics of HSF1 Conditional Knock Out in the Adult Mouse Brain
