PXD082052

PXD082052 is an original dataset announced via ProteomeXchange.

Title	Integrated N- and O-glycoproteomics reveals site-specific glycosylation dysregulation in Alzheimer's disease
Description	This study performed integrated intact N- and O-glycoproteomic profiling of human serum from normal controls (n=10), patients with mild cognitive impairment (MCI, n=10), and patients with Alzheimer's disease (AD, n=9). A total of 2,433 intact N-glycopeptides and 3,864 intact O-glycopeptides were identified, providing a site-resolved view of systemic glycosylation changes during disease progression. Quantitative analysis revealed distinct remodeling patterns for N- and O-glycosylation, with early reduction of IGHG1 Asn180 N-glycoforms at MCI stage and progressive increase of APOE O-glycoforms from control to MCI and AD.
HostingRepository	iProX
AnnounceDate	2026-08-01
AnnouncementXML	Submission_2026-08-03_00:16:14.638.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhuo Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2026-08-03 00:15:55	ID requested
⏵ 1	2026-08-03 00:16:15	announced

Dataset with its publication pending

submitter keyword: Alzheimer's disease, Glycoproteomics, Intact glycopeptides, Glycosylation remodeling, Immunoglobulin G, Apolipoprotein E

Hongqiang Qin
contact affiliation	Dalian University of Technology
contact email	qinhq@dlut.edu.cn
lab head
Zhuo Zhang
contact affiliation	Northeastern University
contact email	zhangzhuo2121@126.com
dataset submitter

iProX dataset URI