⮝ Full datasets listing
PXD081978
PXD081978 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Single-molecule chromatin tracing reveals a diversity of megabase heterochromatin domains |
| Description | Chromosomes fold into distinct domains that regulate transcription, replication, and repair. Beyond well-characterized TADs and compartments, the diversity of heterochromatin domains remains poorly defined at the sequence level. Using single-molecule tracing of nascent heterochromatin in C. elegans, we identify three classes of megabase-scale domains: (i) sharp-boundary, Condensin I-dependent Topological Associating Domain-like domains (TADLs), which arise prior to zygotic genome activation; (ii) similarly sized, but Condensin-independent, elegans Condensin-Independent Domains (elCIDs), one of which encompasses the 5S-Spliced Leader repeat locus; and (iii) decompacted, diffuse structures that are abundant in the population, but likely missed by crosslinking assays. Condensin I sits at the border of the TADL domain whereas DNA binding proteins, active histone marks and maternally active genes flank the elCID domains, suggesting boundaries are established by distinct mechanisms for different types of domains. Our results uncover previously unrecognized heterochromatin architectures and implicate maternal transcriptional activity in shaping domain boundaries in early embryos in C. elegans. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-07-31 |
| AnnouncementXML | Submission_2026-07-31_04:21:36.854.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | danilo ritz |
| SpeciesList | scientific name: Caenorhabditis elegans; common name: roundworm; NCBI TaxID: 6239; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Ultra 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-31 03:18:13 | ID requested | |
| ⏵ 1 | 2026-07-31 04:21:37 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Single-molecule chromatin tracing reveals a diversity of megabase heterochromatin domains, DatasetType:Proteomics |
Contact List
| Alexander Schmidt | |
|---|---|
| contact affiliation | Biozentrum, Universtiy of Basel, 4056 Basel, Switzerland |
| contact email | alex.schmidt@unibas.ch |
| lab head | |
| danilo ritz | |
| contact affiliation | University of Basel |
| contact email | danilo.ritz@unibas.ch |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v14/MSV000102679/ |
