⮝ Full datasets listing
PXD081825
PXD081825 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting EGFR to reverse PFOA-induced paradoxical hepatic lipotoxicity and cachexia-like phenotype |
| Description | Perfluorooctanoic acid (PFOA) is linked to metabolic disease, yet its impact on hepatic metabolism remains unclear. We exposed Western diet-fed mice to environmentally relevant PFOA and found that it did not cause classical hepatic steatosis. Instead, PFOA produced a cachexia-like phenotype, with peripheral fat loss, hepatomegaly, liver injury, and systemic inflammation, together with a paradoxical lipid response in which circulating lipids and hepatic lipid droplets fell while hepatic cholesterol rose. By combining metabolomics, 4D-DIA proteomics, network toxicology, and deep-learning, we identified EGFR as a shared target of PFOA and naringenin (NAR). PFOA bound EGFR, hyperactivating EGFR-STAT3 signaling to accelerate fatty acid oxidation and SREBP2-driven cholesterol biosynthesis, while inflammation suppressed HSD11B2 and raised corticosterone. NAR engaged the same target, restrained this signaling, and reversed metabolic dysregulation and inflammation while restoring HSD11B2. Ultimately, PFOA hepatotoxicity is not driven by steatosis and identify EGFR as a candidate target in pollutant-associated metabolic disease. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-28 |
| AnnouncementXML | Submission_2026-07-28_20:25:39.851.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Haotian Li |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-28 20:20:47 | ID requested | |
| ⏵ 1 | 2026-07-28 20:25:40 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: PFOA |
Contact List
| Biran Zhu | |
|---|---|
| contact affiliation | Hubei University Of Chinese Medicine |
| contact email | zhubir@hotmail.com |
| lab head | |
| Haotian Li | |
| contact affiliation | Hubei University Of Chinese Medicine |
| contact email | 18971508407@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
