⮝ Full datasets listing
PXD081427
PXD081427 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ATRIP Lactylation Induces Cell Cycle Arrest Escape and Chemoresistance |
| Description | Elevated lactate levels were associated with chemoresistance across multiple cancer types. Mechanistically, lactylation of ATRIP at lysine 270 (Lac-K270) enhanced ATR-ATRIP interaction, resulting in aberrant ATR activation and subsequent checkpoint kinase 1 (CHK1) degradation via the ubiquitin-proteasome pathway. This rewired the ATR-CHK1 DDR pathway, enabling cancer cells to bypass chemotherapy-induced cell cycle arrest and survive genotoxic stress. Lac-K270 was catalyzed by alanyl-tRNA synthetase 1 (AARS1) and reversed by the deacetylase sirtuin 1 (SIRT1). Pharmacological inhibition of Lac-K270 with alaninol effectively re-sensitized chemoresistant tumors to genotoxic drugs in both in vitro and animal models. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-21 |
| AnnouncementXML | Submission_2026-07-21_19:31:04.394.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yunzi Mao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | lactic acid |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-21 19:30:07 | ID requested | |
| ⏵ 1 | 2026-07-21 19:31:04 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Lactate, chemoresistance |
Contact List
| Yunzi Mao | |
|---|---|
| contact affiliation | Fudan University |
| contact email | maoyz@fudan.edu.cn |
| lab head | |
| Yunzi Mao | |
| contact affiliation | Fudan University |
| contact email | maoyz@fudan.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
