⮝ Full datasets listing
PXD081266
PXD081266 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic profiling of DLG4-mutant patient-derived cortical organoids and AAV-mediated gene replacement in DLG4-related synaptopathy |
| Description | Cortical organoids derived from patients with DLG4-related synaptopathy were used to characterize the proteomic consequences of PSD-95 deficiency and its restoration. The dataset comprises DIA proteomics of organoids carrying loss-of-function DLG4 variants (nonsense and frameshift), their respective parental controls, and mutant organoids following AAV-mediated DLG4 gene replacement (AAV7m8-DLG4, human synapsin promoter). Samples were acquired on an Orbitrap Astral and processed with DIA-NN in library-free mode. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-07-22 |
| AnnouncementXML | Submission_2026-07-22_11:21:54.587.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Paulo C Carvalho |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-17 12:07:30 | ID requested | |
| ⏵ 1 | 2026-07-22 11:21:55 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Cortical organoids, DLG4, PSD-95, DatasetType:Proteomics |
Contact List
| Alysson Muotri | |
|---|---|
| contact affiliation | university of california, sd |
| contact email | muotri@health.ucsd.edu |
| lab head | |
| Paulo C Carvalho | |
| contact affiliation | Fiocruz |
| contact email | pcarvalho751975@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000102520/ |
