⮝ Full datasets listing
PXD081170
PXD081170 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | HSD17B4 interactome in mouse keratinocytes reveals association with splicing factors and RNA processing |
| Description | This project aims to elucidate the molecular mechanism by which HSD17B4 regulates CYP7B1 expression in mouse keratinocytes (mKCs). To identify proteins that interact with HSD17B4, we performed co-immunoprecipitation (Co-IP) using an HSD17B4-specific antibody, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The raw mass spectrometry data were acquired and processed to identify HSD17B4-interacting proteins. Subsequent Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of the HSD17B4 interactome revealed a significant overrepresentation of proteins involved in RNA splicing and RNA processing. These findings suggest that HSD17B4 may regulate CYP7B1 expression through interactions with splicing factors, pointing to a previously unrecognized nuclear function of HSD17B4 beyond its enzymatic activity. This project contains the MS data for the interacting protein of HSD17B4 we identified. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-16 |
| AnnouncementXML | Submission_2026-07-16_01:43:26.180.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jing Bai |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-16 01:43:10 | ID requested | |
| ⏵ 1 | 2026-07-16 01:43:26 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: HSD17B4, splicing factor, RNA processing, keratinocyte |
Contact List
| Honglin Wang | |
|---|---|
| contact affiliation | Shanghai Jiao Tong University |
| contact email | Honglin.wang@sjtu.edu.cn |
| lab head | |
| Jing Bai | |
| contact affiliation | Shanghai Jiao Tong University |
| contact email | baijing1982@sjtu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
