⮝ Full datasets listing
PXD081033
PXD081033 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Unctional characterization of corn tripeptide Leu-Pro-Pro as a novel anti-rheumatoid arthritis agent: Multi-omics insights into its immunomodulatory and anti-inflammatory mechanisms |
| Description | Rheumatoid arthritis (RA) is a refractory chronic autoimmune disease, and there is an urgent demand for safe and efficient natural therapeutic alternatives. This study aimed to investigate the anti-arthritic efficacy and underlying molecular mechanism of corn tripeptide Leu-Pro-Pro (LPP). In vitro experiments verified that compared with structurally homologous Ile-Pro-Pro and Val-Pro-Pro, LPP significantly inhibited the proliferation and inflammatory activation of HFLS-RA and RAW264.7 cells, and displayed favorable biosafety without damaging normal somatic cells. In vivo animal assays demonstrated that LPP could dose-dependently reduce joint swelling degree and arthritis clinical scores, remarkably improve pathological changes of joint tissues, inhibit synovial hyperplasia and cartilage degradation, ameliorate trabecular bone microstructure damage, and restore the disordered secretion of multiple inflammatory cytokines. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-14 |
| AnnouncementXML | Submission_2026-07-14_00:56:23.015.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nan Wu |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-14 00:56:01 | ID requested | |
| ⏵ 1 | 2026-07-14 00:56:23 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Food-derived tripeptides |
| Rheumatoid arthritis |
| Multi-omics analysis |
| Metabolic regulation |
| Intestinal microbiota |
Contact List
| Chenghao Jin | |
|---|---|
| contact affiliation | Heilongjiang Bayi Agricultural University |
| contact email | jinchenghao3727@byau.edu.cn |
| lab head | |
| Nan Wu | |
| contact affiliation | Heilongjiang Bayi Agricultural University |
| contact email | wunan0925@byau.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
