⮝ Full datasets listing
PXD080966
PXD080966 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tumor-Derived Extracellular Vesicle Proteomics Enables Precise Ovarian Cancer Liquid Biopsy |
| Description | Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, and effective non-invasive biomarkers for early diagnosis, postoperative monitoring, and prognosis assessment are still limited. Serum CA125, the current standard biomarker for OC, has limited diagnostic accuracy, particularly in early-stage disease. Cancer-derived extracellular vesicles (EVs) carry tumor-specific proteomic information and represent promising biomarkers; however, their sensitive and specific isolation from complex biological fluids remains challenging. In this project, we developed BP-EVlent, a novel approach that combines polyethylene glycol (PEG)-based precipitation with CA125 immunoaffinity capture to precisely isolate plasma CA125-positive EVs from patients with OC. The performance of BP-EVlent was evaluated using data-independent acquisition mass spectrometry (DIA-MS)-based proteomic analysis of plasma samples from healthy controls (HC), preoperative OC patients (OC-pre), and postoperative OC patients (OC-post |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-13 |
| AnnouncementXML | Submission_2026-07-13_02:18:17.490.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xianzhong Cheng |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | wavelength array |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-13 02:17:48 | ID requested | |
| ⏵ 1 | 2026-07-13 02:18:18 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ovarian cancer, BP-EVlent, CA125-positive extracellular vesicles, four-molecule signature, non-invasive diagnosis |
Contact List
| Xianzhong Cheng | |
|---|---|
| contact affiliation | The Affiliated Cancer Hospital of Nanjing Medical University |
| contact email | cxxxxcyd@gmail.com |
| lab head | |
| Xianzhong Cheng | |
| contact affiliation | The Affiliated Cancer Hospital of Nanjing Medical University |
| contact email | cxxxxcyd@gmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
