PXD080958

PXD080958 is an original dataset announced via ProteomeXchange.

Title	Quantitative succinylome analysis of mouse primary hepatocytes using 4D Fast DIA proteomics
Description	This study employed a quantitative sarkosylation group analysis based on 4D rapid DIA to investigate the changes in protein sarkosylation in mouse primary hepatocytes. For the accuracy of the results, we first conducted protein quantification, followed by the detection of sarkosylation. The experiment included four treatment groups, with three biological replicates in each group, totaling 12 samples. After protein extraction, enzymatic digestion, and sarkosylation peptide enrichment, the samples were analyzed using liquid chromatography-tandem mass spectrometry. The generated data set included raw mass spectrometry files and processed quantitative data, which could be used to identify differentially sarkosylated proteins and explore the potential biological functions of lysine sarkosylation
HostingRepository	iProX
AnnounceDate	2026-08-14
AnnouncementXML	Submission_2026-08-14_00:42:34.253.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ting Lei
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	N6-succinyl-L-lysine
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-07-13 01:45:58	ID requested
⏵ 1	2026-08-14 00:42:34	announced

Dataset with its publication pending

submitter keyword: mouse, primary hepatocytes, protein succinylation

Jin Hou
contact affiliation	Naval Medical University, National Key Laboratory of Immunity and Inflammation
contact email	houjinsmmu@126.com
lab head
Ting Lei
contact affiliation	Naval Medical University，National Key Laboratory of Immunity and Inflammation
contact email	tinglei2023@yeah.net
dataset submitter

iProX dataset URI