PXD080883

PXD080883 is an original dataset announced via ProteomeXchange.

Title	Human gastric cardia adenocarcinoma LC-MSMS
Description	Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using Mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics. Based on HER2 expression levels, we categorized patients into HER2-high, - low, and -negative groups and confirmed the favorable prognostic significance of HER2. We uncovered an enrichment of DNA repair features in the HER2-high group, while HER2-low and -negative groups exhibited strong inflammation. We found that tumor mutation burden may not be the distinguishing factor among these three groups. We revealed that the HER2- negative and -low groups have a tumor-suppressive immune microenvironment. Our study revealed that anti-inflammatory approaches and immune checkpoint inhibition targeting the CD47/SIRPA axis may serve as therapeutic strategies for patients with HER2-negative GCA. These findings highlight promising avenues for personalized treatment of GCA.
HostingRepository	PRIDE
AnnounceDate	2026-07-12
AnnouncementXML	Submission_2026-07-12_02:21:12.764.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Li Dong Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2026-07-11 06:20:45	ID requested
⏵ 1	2026-07-12 02:21:13	announced

Dataset with its publication pending

submitter keyword: Human gastric cardia adenocarcinoma tumor and its normal adjacent tissues LC-MSMS

Li Dong Wang
contact affiliation	State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key 7 Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou 8 University, Zhengzhou 450052, China.
contact email	ldwang2007@126.com
lab head
Li Dong Wang
contact affiliation	The First Affiliated Hospital of Zhengzhou University
contact email	ldwang2007@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD080883

PRIDE project URI

• PRIDE
  1. PXD080883
     1. Label: PRIDE project
     2. Name: Human gastric cardia adenocarcinoma LC-MSMS