PXD080849 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of lactate-induced PGK1 K131 lactylation in hepatocellular carcinoma cells |
| Description | Lactate accumulation is an important metabolic feature of hepatocellular carcinoma and may regulate tumor progression through lactate-dependent post-translational modifications. In this study, we investigated whether lactate-induced protein lactylation contributes to the regulation of phosphoglycerate kinase 1 (PGK1) in hepatocellular carcinoma cells. HCC cells were treated with lactate, and endogenous PGK1 was immunoprecipitated for mass spectrometry analysis. LC-MS/MS analysis identified lysine lactylation of PGK1, with K131 detected as a lactylated residue. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-04 |
| AnnouncementXML | Submission_2026-09-04_01:47:19.857.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Rongxuan Zhu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | 4700 Proteomics Analyzer |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-07-10 07:53:20 | ID requested | |
| ⏵ 1 | 2026-09-04 01:47:20 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Human |
| Hepatocellular carcinoma |
| HCC |
| Lactate |
| Protein lactylation |
| Lysine lactylation |
| PGK1 |
| K131 |
| Immunoprecipitation |
| LC-MS/MS |
| Tandem mass spectrometry |
| Post-translational modification |
Contact List
| rongxuan zhu |
|---|
| contact affiliation | zhejiang university |
| contact email | jnuzrx@163.com |
| lab head | |
| Rongxuan Zhu |
|---|
| contact affiliation | Zhejiang University |
| contact email | jnuzrx@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD080849 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD080849
- Label: PRIDE project
- Name: Identification of lactate-induced PGK1 K131 lactylation in hepatocellular carcinoma cells
