⮝ Full datasets listing
PXD080784
PXD080784 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic profiling of LX-2 cells treated with TGF-beta and DOX versus TGF-beta alone |
| Description | This project aims to investigate whether doxycycline (DOX) can attenuate TGF-β1-induced fibrotic activation in human hepatic stellate LX-2 cells. We performed quantitative proteomic analysis using LC-MS/MS to compare protein expression profiles between TGF-β1-treated and TGF-β1 plus DOX-treated groups. The results will reveal potential anti-fibrotic mechanisms of DOX and identify key proteins and pathways involved in the regulation of hepatic fibrosis. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-09 |
| AnnouncementXML | Submission_2026-07-14_01:27:06.261.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kun Cao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-09 00:29:46 | ID requested | |
| ⏵ 1 | 2026-07-14 01:27:06 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: LX-2, Hepatic stellate cell, TGF-β1, Doxycycline, Proteomics |
Contact List
| Kun Cao | |
|---|---|
| contact affiliation | The First Dongguan Affiliated Hospital of Guangdong Medical University |
| contact email | caokun@gdmu.edu.cn |
| lab head | |
| Kun Cao | |
| contact affiliation | The First Dongguan Affiliated Hospital of Guangdong Medical University |
| contact email | caokun@gdmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
