PXD080675 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression |
| Description | This project includes raw mass spectrometry data supporting the identification of phosphorylation sites on AEG-1 (MTDH), particularly S426 and T492, in gastric cancer cells（BGC823） under CXCL12 treatment, as well as PPP1R21-interacting proteins including AEG-1 in HEK293T cells. This result supports the main findings of the manuscript accepted in the Journal of Biological Chemistry. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-07 |
| AnnouncementXML | Submission_2026-07-07_06:26:05.839.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | XUERONG WANG |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-07-07 05:42:41 | ID requested | |
| ⏵ 1 | 2026-07-07 06:26:13 | announced | |
Publication List
| 10.1016/j.jbc.2025.110687; |
| Zhao L, Qian X, Fan Y, Li H, Zhang Z, Chen C, Yang L, Yu S, Wang X, Huang W, Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression. J Biol Chem, 301(10):110687(2025) [pubmed] |
Keyword List
| submitter keyword: gastric cancer |
| phosphorylation |
| astrocyte elevated gene-1 |
| eukaryocytic translation initiation factor 4E |
| phosphotase protein 1 regulatory subunit 21 |
| nuclear factor kappa B |
Contact List
| Xuerong Wang |
|---|
| contact affiliation | Department of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu Province, China 210029 |
| contact email | wangxr@njmu.edu.cn |
| lab head | |
| XUERONG WANG |
|---|
| contact affiliation | Nanjing Medical University |
| contact email | wangxrwn@hotmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD080675 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD080675
- Label: PRIDE project
- Name: Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression
