⮝ Full datasets listing
PXD080621
PXD080621 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Advantages of Pooled-Donor Culture of Foreskin Mesenchymal Stromal Cells for Extracellular Vesicle Production: Insights from Multi-Omics Analysis |
| Description | This project characterizes the proteomic landscape of small extracellular vesicles (sEVs) derived from human adipose-, foreskin-, and umbilical cord-derived mesenchymal stromal cells (MSCs) cultured under single-donor or pooled-donor conditions in conventional 2D culture and 3D microcarrier-based bioreactors. DIA-based quantitative proteomics was used to determine how donor pooling and 3D culture reshape sEV cargo composition, reduce batch-level heterogeneity, and establish conserved protein signatures across tissue sources. The dataset identifies manufacturing-responsive molecular programs related to mitophagy, immune communication, phagocytosis, membrane repair, wound healing, and mitochondrial metabolism. Foreskin-derived MSC-sEVs showed the strongest response to pooled-donor and 3D culture conditions, supporting their potential as a platform for engineered immuno-mitochondrial and reparative vesicle products. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-05 |
| AnnouncementXML | Submission_2026-07-06_18:28:43.344.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chui Qin |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-06 18:28:26 | ID requested | |
| ⏵ 1 | 2026-07-06 18:28:43 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Mesenchymal stromal cells, small extracellular vesicles, MSC-sEVs, donor pooling, pooled-donor culture, 3D bioreactor culture, foreskin-derived MSCs, DIA proteomics, multi-omics, regenerative medicine |
Contact List
| Lian Ma | |
|---|---|
| contact affiliation | West China Second Hospital of Sichuan University |
| contact email | malian8965@sina.com |
| lab head | |
| Chui Qin | |
| contact affiliation | West China Second Hospital of Sichuan University |
| contact email | 19cqfan@alumni.stu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
