⮝ Full datasets listing
PXD080461
PXD080461 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting F₁F₀-ATP Synthase Vulnerability: A Strategy to Overcome Antifungal Resistance |
| Description | The global spread of drug-resistant fungi poses a severe challenge to the clinical treatment of invasive fungal disease (IFD). It remains unknown how drug-resistant fungi adapt to drug pressure through metabolic remodeling. We discovered that drug-resistant fungi undergo energy metabolism reprogramming, becoming highly dependent on the F₁F₀-ATP synthase, a key hub of the oxidative phosphorylation (OXPHOS) pathway, for survival. Notably, this 'metabolic addiction' is accompanied by a decline in the stress tolerance of F₁F₀-ATP synthase in both function and structure, rendering it an unexpected 'metabolic vulnerability.' Mechanistic studies indicate that the upregulated molecular chaperone HSP90 interacts with the OSCP subunit of the enzyme to enhance its activity, thereby promoting massive ATP production. However, this process drives mitochondrial hyperfunction, induces oxidative stress, and consequently impairs the functional and structural stability of F₁F₀-ATP synthase. Based on this unique vulnerability, we screened for the inhibitor F6, which specifically targets the OSCP subunit of F₁F₀-ATP synthase. F6 exhibits potent antifungal activity against drug-resistant fungi and acts synergistically with first-line clinical antifungal agents. It effectively reverses drug resistance without inducing a high risk of drug or cross-resistance. In summary, targeting the vulnerability of F₁F₀-ATP synthase in drug-resistant fungi may provide a new strategy for overcoming clinical fungal resistance. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-01 |
| AnnouncementXML | Submission_2026-07-01_19:53:29.695.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xiaoting Yu |
| SpeciesList | scientific name: Candida albicans; NCBI TaxID: 5476; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-01 19:53:03 | ID requested | |
| ⏵ 1 | 2026-07-01 19:53:30 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Antifungal Resistance,F₁F₀-ATP Synthase,Metabolic vulnerability,Targeted inhibitor |
Contact List
| Hong Zhang | |
|---|---|
| contact affiliation | Jinan University |
| contact email | 17879552721@163.com |
| lab head | |
| Xiaoting Yu | |
| contact affiliation | Jinan University |
| contact email | yuxiaoting@stu2021.jnu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
