⮝ Full datasets listing
PXD080431
PXD080431 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TAF7 accumulates in the cytoplasm during cellular transformation and engages STAT3, WASH, and CCT |
| Description | TAF7, a core subunit of the general transcription factor TFIID, regulates transcription and additionally functions as an RNA chaperone that directs nascent nuclear RNAs to cytoplasmic polysomes, thereby influencing protein synthesis. Here, we identify a set of novel cytoplasmic interactors and a previously unappreciated cytoplasmic role for TAF7 in oncogenesis. BioID-mediated proximity labeling identified STAT3 and the CCT and WASH complexes as prominent cytoplasmic interactors of TAF7. These interactions were validated by co-immunoprecipitation and proximity ligation assays. We further showed that cytoplasmic TAF7 levels increased during oncogenesis in proportion to cancer cell pathogenicity. Notably, TAF7 engagement with STAT3,CCT and WASH complexes is markedly enhanced during cellular transformation, consistent with their functions in cancer progression. Together, these findings reveal a cytoplasmic TAF7 interactome and implicate elevated cytoplasmic TAF7 as associated with oncogenesis. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-07-01 |
| AnnouncementXML | Submission_2026-07-01_07:32:18.687.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Bj�rn H�upl |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl; Oxidation; Acetyl |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-01 06:57:12 | ID requested | |
| ⏵ 1 | 2026-07-01 07:32:19 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: cytoplasmic TAF7, oncogenesis, transformation, STAT3, CCT, WASH, DatasetType:Proteomics |
Contact List
| Dinah S. Singer | |
|---|---|
| contact affiliation | Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD |
| contact email | Dinah.singer@nih.gov |
| lab head | |
| Bj�rn H�upl | |
| contact affiliation | DKFZ/DKTK |
| contact email | b.haeupl@dkfz-heidelberg.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000102325/ |
