PXD080387

PXD080387 is an original dataset announced via ProteomeXchange.

Title	Plasma proteomics in early neonatal life: DIA-based analysis of 51 healthy term newborns from Papua New Guinea within the first 24 hours after birth
Description	Early postnatal life involves rapid physiological and immunological adaptation as the newborn transitions from intrauterine to extrauterine conditions. These processes are reflected in the circulating plasma proteome and affect key blood functions, including homeostasis, hemostasis, and immune defense. During pregnancy, immune tolerance is tightly regulated within the largely sterile intrauterine environment. After birth, the neonatal immune system undergoes rapid maturation to balance antimicrobial defense with colonization by commensal microbes. This early-life immune development, primarily driven by innate immune mechanisms and maternally derived antibodies, has long-term implications for health and disease and exhibits sex-specific characteristics. To characterize early plasma proteome dynamics, we established a well-controlled cohort of 51 healthy term newborns enrolled in Papua New Guinea (PNG) as part of the NIH/NIAID Human Immunology Project Consortium (HIPC). Peripheral blood samples were obtained from all participants within the first 24 hours of life (Day of Life 0).
HostingRepository	PRIDE
AnnounceDate	2026-08-17
AnnouncementXML	Submission_2026-08-17_06:56:40.379.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jing Chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-30 11:24:55	ID requested
⏵ 1	2026-08-17 06:56:40	announced

Dataset with its publication pending

submitter keyword: Proteomics

plasma

neonatal biology

early life

data-independent acquisition

DIA

diaPASEF

mass spectrometry

innate immunity

ontogeny

Hanno Steen
contact affiliation	Boston Children’s Hospital
contact email	hanno.steen@childrens.harvard.edu
lab head
Jing Chen
contact affiliation	Boston Children's Hospital
contact email	jing.chen2@childrens.harvard.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD080387
     1. Label: PRIDE project
     2. Name: Plasma proteomics in early neonatal life: DIA-based analysis of 51 healthy term newborns from Papua New Guinea within the first 24 hours after birth