⮝ Full datasets listing
PXD080312
PXD080312 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | proteomic profiling of exosomes from specimen-derived blood in colorectal cancer |
| Description | Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, necessitating the discovery of novel prognostic biomarkers. Tumor-derived exosomes are emerging as rich reservoirs of protein biomarkers; however, accessing sufficient quantities of tumor-proximal material remains challenging. In this study, we introduce specimen-derived blood (sdBlood), collected immediately after surgical resection of CRC specimens, as a novel and enriched source for tumor-proximal exosome isolation. We employed label-free LC-MS/MS-based proteomics to comprehensively profile the exosomal proteome from sdBlood and compared it with matched peripheral venous blood to identify differentially enriched proteins. Our analyses revealed a distinct proteomic signature in sdBlood-derived exosomes, with several proteins showing significant prognostic potential in publicly available CRC cohorts. This project encompasses the full proteomic dataset generated from these analyses. The data provide a valuable resource for understanding the tumor microenvironment and support the potential of sdBlood as a promising liquid biopsy substrate for prognostic biomarker discovery in colorectal cancer. |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-29 |
| AnnouncementXML | Submission_2026-06-29_02:24:40.438.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Muqing Yang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-29 02:24:21 | ID requested | |
| ⏵ 1 | 2026-06-29 02:24:40 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Colorectal cancer,Exosomes,Specimen-derived blood,LC-MS/MS,Biomarker,Prognosis,Extracellular vesicles |
Contact List
| Muqing Yang | |
|---|---|
| contact affiliation | Tongji Hospital of Tongji University |
| contact email | andyymq@tongji.edu.cn |
| lab head | |
| Muqing Yang | |
| contact affiliation | Tongji Hospital of Tongji University |
| contact email | andyymq@tongji.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
