PXD080150

PXD080150 is an original dataset announced via ProteomeXchange.

Title	LncRNA TAAL regulates TIE1-mediated vascular remodeling and is associated with Diabetic Retinopathy
Description	TIE1, an endothelial receptor-tyrosine-kinase, plays a crucial role in vascular development and remodeling, including in diseases such as diabetic retinopathy (DR). However, the molecular mechanisms and regulatory interactome governing TIE1 function remain largely unknown in endothelial biology. This study was designed to identify long noncoding-RNA (lncRNA) regulators of TIE1 and to elucidate their functional roles in endothelial biology. Through integrative screening and functional assays, we discovered a novel lncRNA, TIE1-associated angiogenic lncRNA (TAAL), that modulates TIE1 function and signaling during vascular-remodeling. Further analyses revealed that dysregulation of the TAAL–TIE1-axis is associated with pathological vascular changes observed in DR, highlighting its potential relevance to disease progression.
HostingRepository	PRIDE
AnnounceDate	2026-08-02
AnnouncementXML	Submission_2026-08-02_09:21:18.216.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lakshita Sharma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q TRAP

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-25 00:04:50	ID requested
⏵ 1	2026-08-02 09:21:18	announced

Dataset with its publication pending

submitter keyword: Tie1,lncRNA TAAL

Dr. Rajender K Motiani
contact affiliation	Associate Professor - Regional Centre for Biotechnology(RCB) 36 Faridabad, Delhi-NCR, India
contact email	rajender.motiani@rcb.res.in
lab head
Lakshita Sharma
contact affiliation	Chair of Biochemistry II, University Wuerzburg
contact email	lakshita.sharma@uni-wuerzburg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD080150

PRIDE project URI

• PRIDE
  1. PXD080150
     1. Label: PRIDE project
     2. Name: LncRNA TAAL regulates TIE1-mediated vascular remodeling and is associated with Diabetic Retinopathy