⮝ Full datasets listing
PXD080057
PXD080057 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Circulating cochlin LCCL domain binds apoptotic and necrotic cells and enhances efferocytosis |
| Description | Clearance of dead cells by efferocytosis is a critical process for homeostasis as, in particular, it limits inflammation. Defect in efferocytosis has been associated to autoimmune, neurodegenerative and cardiovascular diseases, as well as to chronic infections. Better understanding of efferocytosis regulation may pave the way to therapeutically target this process. Here, we identified circulating cochlin LCCL domain as a new regulator of efferocytosis. While the protective role of cochlin in the antibacterial response of the host is now well-established, the underneath mechanisms remained unknown. Using cell binding assay for recombinant cochlin LCCL domain, we established its specific tropism for apoptotic and necrotic but not pyroptotic and necroptotic cells, of both immune and non-immune lineage, from murine as well as human origins. By three independent functional assays, we demonstrated that endogenous and exogenous cochlin LCCL domain enhances macrophage efferocytosis in vitro and in vivo in LPS-induced inflammation and Pseudomonas aeruginosa intranasal infection contexts. Our findings provide a new role of cochlin LCCL domain in the regulation of efferocytosis, in addition to its described proinflammatory role, as an immunomodulator for host response and homeostasis. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-06-23 |
| AnnouncementXML | Submission_2026-06-23_06:32:55.295.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Stefan Tholen |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF fleX |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-23 06:04:15 | ID requested | |
| ⏵ 1 | 2026-06-23 06:32:55 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: cochlin, LCCL, efferocytosis, apoptosis, necrosis, phagocyte, macrophage, inflammation, DatasetType:Proteomics |
Contact List
| Dr. Fabienne Venet | |
|---|---|
| contact affiliation | Centre International de Recherche en Infectiologie Lyon |
| contact email | fabienne.venet@chu-lyon.fr |
| lab head | |
| Stefan Tholen | |
| contact affiliation | Uniklinik Freiburg |
| contact email | stefan.tholen@uniklinik-freiburg.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000102248/ |
