⮝ Full datasets listing
PXD080026
PXD080026 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Protein-resolved multi-omic mapping identifies convergent host regulatory nodes in henipa-related paramyxoviruses |
| Description | Protein-resolved multi-omic mapping defines a comparative virus–host atlas for LayV, NiV and HeV, integrating interactomes, matched transcriptomes, quantitative proteomes and structural models across 26 viral proteins. Henipa-related viral proteins retain substantial interaction specificity, yet converge on shared host regulatory programs, revealing host-node convergence as a conserved organizing principle across divergent paramyxoviruses. Matrix proteins emerge as conserved host-engagement hubs that connect henipa-related viruses to two host-control axes: ABT1-linked transcriptional regulation and MRPS35-linked mitochondrial ribosome function. M–MRPS35 engagement is conserved across multiple henipa-related viruses and is associated with progressive mitochondrial ultrastructural damage, membrane-potential collapse and loss of cellular fitness. ABT1 chromatin profiling reveals that M proteins redirect a basal transcription-associated regulator toward altered antiviral and immune-related transcriptional pro |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-23 |
| AnnouncementXML | Submission_2026-06-22_20:29:36.600.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yawen Zou |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Nipah henipavirus; NCBI TaxID: 121791; scientific name: Hendra virus horse/Australia/Hendra/1994; NCBI TaxID: 928303; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-22 20:28:46 | ID requested | |
| ⏵ 1 | 2026-06-22 20:29:37 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Henipa-related paramyxoviruses, protein-resolved multi-omics, virus–host interactions, host-node convergence, matrix protein |
Contact List
| Yongyong Shi | |
|---|---|
| contact affiliation | Shanghai Jiao Tong University |
| contact email | shiyongyong@gmail.com |
| lab head | |
| Yawen Zou | |
| contact affiliation | Shanghai Jiao Tong University |
| contact email | zouyawen999@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
