⮝ Full datasets listing
PXD079855
PXD079855 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Cyclopeptide 161 protects human dermal fibroblasts against UV-induced damage via the MEK1/2–ERK1/2 signaling pathway |
| Description | This manuscript investigates the mechanistic effects of the cyclic hexapeptide CP161 on human dermal fibroblasts exposed to UV irradiation, emphasizing its role in preserving extracellular matrix homeostasis and mitigating fibroblast senescence. By elucidating the direct interaction between CP161 and MAP2K1, as well as its downstream impact on the MEK1/2–ERK1/2 signaling cascade, this study contributes to a deeper understanding of skin physiology, particularly in response to environmental stressors. |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-18 |
| AnnouncementXML | Submission_2026-06-18_00:57:33.244.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yue Xiao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-18 00:57:14 | ID requested | |
| ⏵ 1 | 2026-06-18 00:57:33 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: cyclopeptide 161, UV irradiation, extracellular matrix, MAP2K1, Munc18a, proteomic analysis. |
Contact List
| Yue Xiao | |
|---|---|
| contact affiliation | Zhejiang University |
| contact email | xiaoyue72@proya.com |
| lab head | |
| Yue Xiao | |
| contact affiliation | Zhejiang University |
| contact email | xiaoyue72@proya.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
