PXD079760

PXD079760 is an original dataset announced via ProteomeXchange.

Title	Design of magnetic cyanidin adsorbent for efficient enrichment of glycoproteins based on synergistic hydrophilic and electrostatic interactions
Description	As one of the most prevalent and crucial post-translational modifications, glycosylation plays a role in diverse biological processes and its abnormal expression is closely associated with various diseases. The direct mass spectrometry analysis of glycoproteins is still a challenge due to their low abundance and the strong ion inhibitory effect from unmodified proteins. In this study, we developed a magnetic cyanidin material, and facilely realized efficient glycoprotein enrichment based on synergistic hydrophilic-electrostatic interactions. The developed method was applied to glycopeptide detection in real human saliva samples and obvious characteristic glycopeptide peaks were detected after enrichment. In addition, glycopeptides were successfully identified in HepG2 cells, demonstrating that the synthesized material broadens the possibility of discovering biomarkers toward hepatocellular carcinoma.
HostingRepository	iProX
AnnounceDate	2026-06-15
AnnouncementXML	Submission_2026-08-31_01:23:57.641.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yongxin Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ZenoTOF 7600

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-16 00:59:57	ID requested
⏵ 1	2026-08-31 01:23:58	announced

Dataset with its publication pending

submitter keyword: glycosylation, enrichment, cyanidin, mass spectrometry

Qiong Jia
contact affiliation	Jilin University
contact email	jiaqiong@jlu.edu.cn
lab head
Yongxin Zhang
contact affiliation	Jilin University
contact email	2788040084@qq.com
dataset submitter

iProX dataset URI