PXD079754 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Analysis of Plasma Membrane Proteins in Atp6ap2 (PRR)-Deficient Osteoblast-Lineage Cells |
| Description | ATP6AP2 (also known as PRR) is required for osteocyte maturation and cortical bone development. To identify downstream effectors of ATP6AP2, plasma membrane-enriched proteins were isolated from control and Atp6ap2-deficient osteoblast-lineage cells and analyzed by mass spectrometry. Comparative proteomic analysis identified MMP14 as a major ATP6AP2-regulated membrane protein. These data support a role for ATP6AP2 in regulating MMP14 surface localization and osteocyte development. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-22 |
| AnnouncementXML | Submission_2026-06-22_08:37:34.174.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD079754 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Belinda Willard |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-06-15 21:52:01 | ID requested | |
| ⏵ 1 | 2026-06-22 08:37:34 | announced | |
Publication List
Keyword List
| submitter keyword: ATP6AP2 |
| MMP14 |
| osteoblast |
| osteocyte |
| cortical bone |
| proteomics |
| mass spectrometry |
| plasma membrane proteins |
| bone development |
Contact List
| Dr. Wen-Cheng Xiong |
|---|
| contact affiliation | Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio, 44106 |
| contact email | Wen-Cheng.Xiong@case.edu |
| lab head | |
| Belinda Willard |
|---|
| contact affiliation | Cleveland Clinic |
| contact email | willarb@ccf.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD079754 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD079754
- Label: PRIDE project
- Name: Proteomic Analysis of Plasma Membrane Proteins in Atp6ap2 (PRR)-Deficient Osteoblast-Lineage Cells
