PXD079729

PXD079729 is an original dataset announced via ProteomeXchange.

Title	Platelet proteomic profiling during active- and sleep-phase ischemic stroke in mice
Description	This project contains mass spectrometry-based platelet proteomic data generated from mice under active-phase sham, sleep-phase sham, active-phase permanent middle cerebral artery occlusion and sleep-phase permanent middle cerebral artery occlusion conditions. The study was designed to investigate how activity–sleep state and cerebral ischemic challenge reshape the platelet proteome. Comparative proteomic analysis was used to identify sleep-phase- and ischemia-associated changes in platelet functional programs, with particular focus on ribosomal structural proteins, mitochondrial dynamics, mitochondrial respiratory proteins and pathways related to platelet activation and thrombosis.
HostingRepository	iProX
AnnounceDate	2026-06-14
AnnouncementXML	Submission_2026-06-15_17:37:25.033.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhuangzhuang Chen
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-15 17:37:04	ID requested
⏵ 1	2026-06-15 17:37:25	announced

Dataset with its publication pending

submitter keyword: platelet proteomics, ischemic stroke, sleep phase, active phase, circadian rhythm, MCAO, mitochondria, ribosome,m, thrombosis, Mus musculus

Yilong Wang
contact affiliation	Beijing Tiantan Hospital, Capital Medical University
contact email	yilong528@aliyun.com
lab head
Zhuangzhuang Chen
contact affiliation	Beijing Tiantan Hospital, Capital Medical University
contact email	chenzz2026@163.com
dataset submitter

iProX dataset URI