PXD079684 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Bos taurus ovarian granulosa cell succinylation |
| Description | Mito-nuclear crosstalk underlying ovarian aging remains elusive. Single-cell transcriptomics of aged ovaries identified senescent signatures including dysregulated mitochondrial metabolism, disturbed histone modification and enriched SASP. We demonstrated that impaired SIRT5-mediated desuccinylation drives ovarian aging. As a major substrate of SIRT5 in the TCA cycle, SUCLG2 is regulated by desuccinylation at K93 and K101, which enhances its stability and activity to rescue mitochondrial dysfunction. Conversely, SUCLG2 hypersuccinylation leads to acetyl-CoA accumulation, increases nuclear H4K8ac and upregulates metabolic genes to compensate for energy deficiency. In vivo experiments showed excess acetyl-CoA accelerates ovarian aging, while a SUCLG2 desuccinylation mutant alleviates this defect. This study reveals the molecular basis of ovarian aging and highlights the SIRT5-SUCLG2 axis as a promising therapeutic target. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-17 |
| AnnouncementXML | Submission_2026-07-17_00:35:02.371.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dejun Xu |
| SpeciesList | scientific name: Bos taurus (Bovine); NCBI TaxID: NEWT:9913; |
| ModificationList | succinylated residue |
| Instrument | timsTOF Pro 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-06-15 00:57:31 | ID requested | |
| ⏵ 1 | 2026-07-17 00:35:02 | announced | |
Publication List
Keyword List
| submitter keyword: LC-MSMS, succinylation, granulosa cell,Bos taurus, ovary |
Contact List
| Dejun Xu |
|---|
| contact affiliation | Southwest University |
| contact email | xdj2020@swu.edu.cn |
| lab head | |
| Dejun Xu |
|---|
| contact affiliation | Southwest University |
| contact email | xdj2020@swu.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD079684
- Label: PRIDE project
- Name: Bos taurus ovarian granulosa cell succinylation
