PXD079554

PXD079554 is an original dataset announced via ProteomeXchange.

Title	Identification of SNHG26-binding proteins in skin fibroblasts by RNA pull-down and LC-MS/MS
Description	This study aims to elucidate the mechanism by which the long non-coding RNA SNHG26 promotes fibroblast activation in keloid pathogenesis through interactions with protein partners. Using RNA pull-down coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified proteins that specifically bind to SNHG26 in primary human keloid-derived fibroblasts. Two independent controls—biotinylated poly(A)25 RNA and a biotinylated random nucleotide sequence—were used to ensure binding specificity. The resulting dataset provides a resource for understanding SNHG26-mediated regulatory mechanisms in fibroblast activation and keloid development.
HostingRepository	iProX
AnnounceDate	2026-06-11
AnnouncementXML	Submission_2026-08-13_19:25:44.143.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ling Pan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-10 20:20:45	ID requested
⏵ 1	2026-08-13 19:25:44	announced

Dataset with its publication pending

submitter keyword: fibroblast, RNA pulldow, LC-MS/MS

Dongqing Li
contact affiliation	Hospital for Skin Diseases,Chinese Academy of Medical Science and Peking Union Medical College
contact email	dongqing1115@163.com
lab head
Ling Pan
contact affiliation	Hospital for Skin Diseases,Chinese Academy of Medical Science and Peking Union Medical College
contact email	283551991@qq.com
dataset submitter

iProX dataset URI