PXD079431 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mass spectrometry-based proteomic characterization of TgGCN5b and TgGNAT2 interactomes |
| Description | Histone acetylation, a fundamental epigenetic mechanism that controls gene activity, is essential for the developmental plasticity and virulence of the parasite Toxoplasma gondii. However, how this parasite organizes and deploys its acetyltransferase machinery has remained unclear. We show that T. gondii rewired this process using a plant-like system built around the acetyltransferase TgGCN5b, which differs from the typical SAGA complex found in other eukaryotes. We complete our interactome analysis by characterizing TgGCN5b interactome in PHD1 KD or AP2XI-2 and AP2XII-1 KD parasites, TgGCN5b interactome from simple and double purifications, and TgGNAT2 interactome. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-25 |
| AnnouncementXML | Submission_2026-07-25_06:30:52.426.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD079431 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Yohann Couté |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Toxoplasma gondii; NCBI TaxID: NEWT:5811; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-06-08 23:35:32 | ID requested | |
| ⏵ 1 | 2026-07-25 06:30:52 | announced | |
Publication List
Keyword List
| submitter keyword: Toxoplasma, acetylation, nanoLC-MS/MS, interactome |
Contact List
| Yohann Couté |
|---|
| contact affiliation | EDyP |
| contact email | yohann.coute@cea.fr |
| lab head | |
| Yohann Couté |
|---|
| contact affiliation | EDyP |
| contact email | yohann.coute@cea.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD079431
- Label: PRIDE project
- Name: Mass spectrometry-based proteomic characterization of TgGCN5b and TgGNAT2 interactomes
