⮝ Full datasets listing
PXD079426
PXD079426 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Capture and quantitative proteomic analysis of amyloid plaque components in 5XFAD mouse brain via probe with wild-type mouse tissue for background subtraction |
| Description | This study utilized the P6 probe to specifically capture protein components deposited within cerebral amyloid plaques from 5XFAD transgenic Alzheimer’s disease model mice. Wild-type (WT) mouse brain tissues were processed in parallel as negative controls to subtract non-specific background binding signals derived from the probe pulldown assay. Captured protein complexes were digested with trypsin, fractionated via liquid chromatography, and profiled using high-resolution LC-MS/MS proteomic technology. Subsequent differential protein screening and functional enrichment analyses were carried out to discover unreported plaque-enriched proteins linked to amyloid aggregation and progressive neurodegeneration. All raw mass spectrometry spectra and peptide identification datasets are archived in this repository to ensure experimental reproducibility and facilitate subsequent mechanistic investigations. |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-09 |
| AnnouncementXML | Submission_2026-06-08_21:29:25.197.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hao Jin |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-08 21:28:32 | ID requested | |
| ⏵ 1 | 2026-06-08 21:29:25 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: proteomics, P6 chemical probe, 5XFAD mouse, Alzheimer’s disease, amyloid plaque, brain tissue, wild-type control, label-free quantification |
Contact List
| Yu Liu | |
|---|---|
| contact affiliation | state Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences |
| contact email | liuyu@dicp.ac.cn |
| lab head | |
| Hao Jin | |
| contact affiliation | state Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences |
| contact email | jinhao@dicp.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
