PXD079354

PXD079354 is an original dataset announced via ProteomeXchange.

Title	Neoantigen Discovery and Validation in Hepatocellular Carcinoma: Unveiling Immunogenic Targets Through Mass Spectrometry
Description	The accurate identification of tumor neoantigens, particularly cryptic antigens from non-canonical translation, is crucial for developing effective cancer immunotherapies. However, the significance and action of cryptic antigens in anti-tumour immunity remain unclear. In this study, we utilized a highly sensitive mass spectrometry-based de novo sequencing approach to identify non-canonical MHC-binding immunopeptides and evaluate the anti-tumor immune effects of vaccines composed of these peptides in Hepatocellular carcinoma (HCC).
HostingRepository	iProX
AnnounceDate	2025-07-25
AnnouncementXML	Submission_2026-06-07_17:59:18.067.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaohua Xing
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-07 17:58:27	ID requested
⏵ 1	2026-06-07 17:59:18	announced

Xing X, Liu M, Ouyang J, Tang Y, Shan B, Tang R, Hu E, Li M, Liu X, Mass spectrometry-based de novo sequencing reveals non-canonical neoantigens with antitumor efficacy in hepatocellular carcinoma. JHEP Rep, 8(4):101775(2026) [pubmed]

submitter keyword: neoantigen，immunopeptidomics，Mass Spectrometer

Xiaolong Liu
contact affiliation	The Liver Center of Fujian Province
contact email	xiaolong.liu@gmail.com
lab head
Xiaohua Xing
contact affiliation	The Liver Center of Fujian Province
contact email	xingxiaohua2006@163.com
dataset submitter

iProX dataset URI