PXD079292 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Human myocardial tissue proteomics associated with late gadolinium enhancement burden in hypertrophic cardiomyopathy |
| Description | This project investigates myocardial tissue proteomic remodeling associated with cardiac magnetic resonance-defined late gadolinium enhancement burden in patients with hypertrophic cardiomyopathy. Myocardial tissue samples were obtained from patients undergoing septal myectomy, and protein abundance profiles were generated using data-independent acquisition liquid chromatography–tandem mass spectrometry. Quantitative LGE burden was measured as the percentage of left ventricular mass using a 6-SD threshold. Proteome-wide association analysis, pathway enrichment analysis, module score construction, and exploratory mediation analysis were performed to identify myocardial molecular programs associated with increasing LGE burden. The study identified coordinated proteomic alterations involving mitochondrial/oxidoreductive dysfunction, complement-mediated inflammatory activation, and nuclear–cytoskeletal–junctional remodelling. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-22 |
| AnnouncementXML | Submission_2026-07-21_23:57:46.225.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | shuo shi |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-06-04 19:03:11 | ID requested | |
| ⏵ 1 | 2026-07-21 23:57:46 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Human myocardial tissue proteomics associated with late gadolinium enhancement burden in hypertrophic cardiomyopathy |
Contact List
| Lei Xu |
|---|
| contact affiliation | Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. |
| contact email | sdshishuo4967@163.com |
| lab head | |
| shuo shi |
|---|
| contact affiliation | Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. |
| contact email | sdshishuo4967@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD079292 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD079292
- Label: PRIDE project
- Name: Human myocardial tissue proteomics associated with late gadolinium enhancement burden in hypertrophic cardiomyopathy
