⮝ Full datasets listing
PXD079284
PXD079284 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | PSMD2 mediates the degradation of CYP1A2 and promotes the progression of MASH |
| Description | This study provides the first evidence that hepatocyte PSMD2 drives MASH pathology by promoting CYP1A2 degradation and lipid accumulation. PSMD2 deficiency alleviates hepatic steatosis, reduces triglyceride and free fatty acid levels, and restores liver function. These findings establish PSMD2 as a critical regulator of lipid metabolism and hepatocyte integrity, positioning it as a promising therapeutic target for MASH intervention. |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-04 |
| AnnouncementXML | Submission_2026-08-13_19:56:32.319.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Min Liu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-04 18:47:50 | ID requested | |
| ⏵ 1 | 2026-08-13 19:56:32 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: PSMD2, MASH, CYP1A2, Proteasome degradation pathway |
Contact List
| Yuan Xie | |
|---|---|
| contact affiliation | China Pharmaceutical University |
| contact email | yuanxie@cpu.edu.cn |
| lab head | |
| Min Liu | |
| contact affiliation | China Pharmaceutical University |
| contact email | 3223071788@stu.cpu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
