⮝ Full datasets listing
PXD079253
PXD079253 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | CBX4 stabilizes NEUROD1 through SUMO-ubiquitin crosstalk to delay β-cell senescence |
| Description | CBX4 expression is progressively lost in aged and diabetic pancreatic β-cells, correlating with cellular senescence. Mechanistically, CBX4 stabilizes NEUROD1 by promoting its SUMOylation at lysine 38, which antagonizes NEDD4-mediated ubiquitination. Stabilized NEUROD1 enhances insulin transcription and activates CaMKII signaling by suppressing Camk2n1 expression. This cascade preserves mitochondrial function and calcium homeostasis in β-cells. Thus, the STAT5A-CBX4-NEUROD1 axis represents a key protective pathway against β-cell aging and a potential therapeutic target for T2DM. |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-04 |
| AnnouncementXML | Submission_2026-06-03_19:46:10.695.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Fangfang Zhang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-03 19:45:53 | ID requested | |
| ⏵ 1 | 2026-06-03 19:46:11 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: β-cell senescence, Chromobox 4, NEUROD1, Calcium signaling, Sumoylation, Phase separation |
Contact List
| Liang Jin | |
|---|---|
| contact affiliation | China Pharmaceutical University |
| contact email | 6238564@qq.com |
| lab head | |
| Fangfang Zhang | |
| contact affiliation | China Pharmaceutical University |
| contact email | zhangff@cpu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
