PXD079252

PXD079252 is an original dataset announced via ProteomeXchange.

Title	Osteocyte Parvalbumin Mediates Mechanotransduction to Attenuate Osteoarthritis
Description	Osteoarthritis (OA) is a leading cause of disability among the elderly, characterized by aberrant subchondral bone remodeling that precedes cartilage degeneration. We identify parvalbumin (Pvalb) in osteocytes as a critical mechanosensory regulator of this pathological process. Pvalb expression is significantly reduced in osteocytes from both OA patients and male murine models of the disease. Conditional deletion of Pvalb in osteocytes accelerates OA progression, whereas bone-targeted restoration of Pvalb expression mitigates disease manifestations. Mechanistically, Pvalb maintains calcium homeostasis by competing with CaMKIV for calmodulin binding. Under excessive mechanical loading, Pvalb expression is suppressed, leading to activation of the Ca²+-CaMKIV-CREB signaling pathway, increased RANKL production, and subsequent osteoclast activation and pathological bone remodeling. These findings identifies an osteocyte-mediated mechanotransduction pathway in OA pathogenesis and underscore Pvalb as a promising therapeutic target.
HostingRepository	iProX
AnnounceDate	2026-06-04
AnnouncementXML	Submission_2026-06-03_19:43:55.113.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiansen Su
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LCQ Deca XP Plus

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-03 19:43:38	ID requested
⏵ 1	2026-06-03 19:43:55	announced

Dataset with its publication pending

submitter keyword: Osteoarthritis, Subchondral bone, Parvalbumin, Osteocyte, Mechanotransduction

Jiansen Su
contact affiliation	Shanghai Sixth People's Hospital
contact email	sujiansen@sjtu.edu.cn
lab head
Jiansen Su
contact affiliation	Shanghai Sixth People's Hospital
contact email	sujiansen@sjtu.edu.cn
dataset submitter

iProX dataset URI