⮝ Full datasets listing
PXD079164
PXD079164 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TRMT61A-mediated tRNA methylation regulates Th17 differentiation via a glycolysis–lactylation axis in autoimmune inflammation |
| Description | To characterize the global landscape of lysine lactylation (Kla) in Th17 cells, we cultured naïve CD4⁺ T cells isolated from Trmt61a-cKO and WT mice under Th17-polarizing conditions for 96 hours. At least 1 × 10⁷ cells per sample were harvested for proteomic analysis. Following tryptic digestion, Kla-modified peptides were enriched using anti-Kla antibodies and analyzed by LC–MS/MS. |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-01 |
| AnnouncementXML | Submission_2026-06-01_20:08:51.225.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jianping Hu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-01 20:08:31 | ID requested | |
| ⏵ 1 | 2026-06-01 20:08:51 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: lactylation |
Contact List
| Xianqun Fan | |
|---|---|
| contact affiliation | Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine |
| contact email | fanxq@sjtu.edu.cn |
| lab head | |
| Jianping Hu | |
| contact affiliation | Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine |
| contact email | jphu1993@hotmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
