⮝ Full datasets listing
PXD079139
PXD079139 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency |
| Description | Medulloblastoma (MB) is a biologically heterogeneous childhood cerebellar tumor harboring frequent chromatin-modifying gene alterations. How these alterations promote transcriptional programs governing malignancy remains poorly defined. To address this knowledge gap, we evaluated chromatin states across MB subgroups by multi-modal integration of histone modifications with mutational, DNA methylation, and transcriptomic profiles. A bivalent/poised enhancer (EnhBiv) state was specifically enriched at the promoters of neurodevelopmental genes in Groups 3- and 4-MB. Integrative bioinformatics coupled with chromatin occupancy studies identified aberrant KDM2B binding at EnhBiv-enriched promoters. CRISPR-mediated knockout or acute protein degradation of KDM2B selectively suppressed the growth of MB models in vitro and in vivo. Mechanistically, KDM2B promotes sequential recruitment of Polycomb repressive complexes (PRC1/PRC2) and EnhBiv chromatin, thereby repressing neuronal differentiation programs. Collectively, we provide foundational insights into an epigenetic basis of MB, nominating KDM2B as a selective dependency in high-risk subgroups that warrants consideration as a candidate therapeutic target. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-06-22 |
| AnnouncementXML | Submission_2026-06-22_08:57:32.048.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ran Tao |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Acetyl; Methyl; Dimethyl; Trimethyl |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-01 09:24:43 | ID requested | |
| ⏵ 1 | 2026-06-22 08:57:32 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: medulloblastoma, epigenomics, histone ChIP-seq, chromatin states, KDM2B, bivalent enhancer, dependency, Polycomb, DatasetType:Proteomics |
Contact List
| Paul A. Northcott | |
|---|---|
| contact affiliation | St. Jude |
| contact email | Paul.Northcott@STJUDE.ORG |
| lab head | |
| Ran Tao | |
| contact affiliation | St. Jude |
| contact email | Ran.Tao@STJUDE.ORG |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000102007/ |
