⮝ Full datasets listing
PXD079113
PXD079113 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ECM1/SQSTM1 Axis Remodels Colorectal Cancer Immune Microenvironment via CXCL1-CXCR2-Dependent Neutrophil Recruitment and NETosis |
| Description | In this study, we demonstrate that ECM1 derived from intestinal epithelial cells (IECs) serves as a critical driver of CRC progression. The deficiency of Ecm1 specifically in intestinal epithelial significantly suppresses both colitis-associated and spontaneous colorectal tumorigenesis in vivo. Through single-cell and spatial transcriptomic analyses, we reveal that ECM1 regulates neutrophil recruitment and activation within the tumor microenvironment (TME). Mechanistically, ECM1 functions as a scaffold protein that facilitates the interaction between SQSTM1 and RIP1, thereby initiating NF-κB-meditated CXCL1 secretion. This signaling pathway recruits neutrophils and induces the formation of neutrophils extracellular traps (NETs), creating an immune barrier that excludes CD8+ T cells. Notably, targeting ECM1 effectively mitigates neutrophil-mediated immunosuppression and reverses anti-PD-1 immunotherapy resistance in subcutaneous tumor-bearing mice. |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-01 |
| AnnouncementXML | Submission_2026-06-01_01:26:32.363.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jian Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-01 01:26:18 | ID requested | |
| ⏵ 1 | 2026-06-01 01:26:32 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Colorectal cancer, ECM1, SQSTM1, NF-κB signaling pathway, CXCL1, Neutrophil extracellular traps, Immunosuppressive tumor microenvironment |
Contact List
| Debing Xiang | |
|---|---|
| contact affiliation | Jiangjin Hospital of Chongqing University |
| contact email | xdb86@cqu.edu.cn |
| lab head | |
| Jian Wang | |
| contact affiliation | Jiangjin Hospital of Chongqing University |
| contact email | wj929@cqu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
