⮝ Full datasets listing
PXD078996
PXD078996 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ribosomal stress responses in bacteria under starvation and hypoxia |
| Description | Bacteria survive stressful conditions by using protective mechanisms such as ribosome hibernation, where specialised proteins called hibernation factors protect inactive ribosomes from degradation. Although these factors were thought to be highly conserved across bacteria, our evolutionary, proteomic, and structural analyses revealed that they are far more diverse than previously recognised. We found that many bacteria possess structurally distinct hibernation-related proteins that respond to specific stresses such as hypoxia, while over 10% of representative bacterial species lack all currently known hibernation factors entirely. Using cryo-EM analysis of one such species, Asaia platycodi, we showed that these bacteria instead display alternative ribosomal stress responses, suggesting that many ribosome hibernation mechanisms remain undiscovered. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-05-29 |
| AnnouncementXML | Submission_2026-05-29_01:49:07.277.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Pawel Palmowski |
| SpeciesList | scientific name: Mycobacterium smegmatis; scientific name: Asaia platycodi; scientific name: Marimonas arenosa; scientific name: Escherichia coli; |
| ModificationList | Acetyl; Oxidation |
| Instrument | Orbitrap Astral Zoom; timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-28 08:23:32 | ID requested | |
| ⏵ 1 | 2026-05-29 01:49:07 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Ribosome hibernation, stress response, starvation, hypoxia, DatasetType:Proteomics |
Contact List
| Sergey V. Melnikov | |
|---|---|
| contact affiliation | Newcastle University |
| contact email | Sergey.Melnikov@newcastle.ac.uk |
| lab head | |
| Pawel Palmowski | |
| contact affiliation | Newcastle University NUPPA |
| contact email | pawel.palmowski@ncl.ac.uk |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000101966/ |
