⮝ Full datasets listing
PXD078995
PXD078995 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ischemic human cardiac microtissue proteome map |
| Description | Advanced human stem cell-based platform provides a cardiac microtissue model to understand nanovesicle-based function and proteome remodelling, with potential applications for disease modelling and therapeutic intervention. Quantitative proteomics was applied to decipher the cell proteome dynamics and molecular mechanisms of IRI in our in vitro model following NV treatment, linked with networks associated with cell survival, energy production, and stress response regulation. Notably, cell type-specific enrichment analysis revealed that NVs drive distinct proteomic remodeling based on their cell origin, where CERA NVs selectively upregulate cytoprotective and structural networks (such as HSP70, MYH6, and XIRP1) within parenchymal cardiomyocytes, whereas CL2 NVs predominantly suppress non-myocyte activation and extracellular matrix remodeling factors within the endothelial and fibroblast compartments. Our findings provide an advanced human stem cell-based platform to understand underlying mechanisms of IRI and assess cell-free therapeutic cardioprotective strategies. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-05-28 |
| AnnouncementXML | Submission_2026-05-28_10:06:55.495.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | David Greening |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Acetyl |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-28 08:23:31 | ID requested | |
| ⏵ 1 | 2026-05-28 10:06:56 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: heart, cardiac microtissue, human iPSC, proteomic reprogramming, nanovesicles, DatasetType:Proteomics |
Contact List
| David Greening | |
|---|---|
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| lab head | |
| David Greening | |
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000101964/ |
