⮝ Full datasets listing
PXD078994
PXD078994 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ischemic cardiac microtissue proteome map |
| Description | We demonstrate use of human cardiac microtissue platform (comprised of cardiomyocyte, fibroblast, and endothelial origin) to model IR injury through hypoxia and reoxygenation and subsequent therapeutic nanovesicle remodelling. Engineered nanovesicles (NVs), generated directly from human stem cells (SC), have been shown to influence cardiac tissue repair, and provide a platform for the reproducible, rapid, and scalable cell free-mediated therapy. Functionally, we demonstrate that administration of NVs (from different human induced pluripotent stem cell (iPSC) origin) during reoxygenation significantly increase cardiomyocyte survival and preserve contractility function (contractile duration, relaxation time, relaxation:contraction velocity). A mass-spectrometry-based proteomics approach was applied to decipher protein dynamics and molecular mechanisms of IR injury in human cardiac microtissues following NV treatments |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-06-01 |
| AnnouncementXML | Submission_2026-06-01_20:33:11.539.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | David Greening |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Acetyl |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-28 08:23:19 | ID requested | |
| ⏵ 1 | 2026-06-01 20:33:12 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: heart, cardiac microtissue, Ischemic, proteome remodelling, DatasetType:Proteomics |
Contact List
| David Greening | |
|---|---|
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| lab head | |
| David Greening | |
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000101962/ |
