PXD078837

PXD078837 is an original dataset announced via ProteomeXchange.

Title	Mouse heart in vivo BioID masspec data
Description	Diastolic dysfunction, defined by increased ventricular stiffness, is a common pathological feature across diverse forms of heart disease and a major contributor to clinical syndromes such as heart failure with preserved ejection fraction. However, the cardiomyocyte-intrinsic mechanisms that lead to diastolic dysfunction remain incompletely understood. We found SORBS2 as a cardiomyocyte-intrinsic regulator of diastolic function. To reveal the underlying mechanism, we used proximity proteomics in intact, living hearts to identify proteins enriched near SORBS2.
HostingRepository	PRIDE
AnnounceDate	2026-05-26
AnnouncementXML	Submission_2026-05-26_05:53:46.569.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD078837
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Fujian Lu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	biotinylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-25 21:45:57	ID requested
⏵ 1	2026-05-26 05:53:47	announced

10.6019/PXD078837;

submitter keyword: in vivo BioID,mouse, heart

William T. Pu
contact affiliation	Department of Cardiology, Boston Children's Hospital
contact email	William.Pu@CARDIO.CHBOSTON.ORG
lab head
Fujian Lu
contact affiliation	Boston Children's Hospital
contact email	fujian.lu@childrens.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD078837

PRIDE project URI

• PRIDE
  1. PXD078837
     1. Label: PRIDE project
     2. Name: Mouse heart in vivo BioID masspec data