⮝ Full datasets listing
PXD078829
PXD078829 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Cracking the Code of Heatstroke: New Insights into Diagnosis and Pathological Mechanisms |
| Description | As global temperatures rise, heatstroke (HS) incidence and mortality have increased significantly, but forensic diagnostic criteria and multi-organ damage mechanisms remain unclear. In this study, a rat model of HS-induced death was established under 39 ± 0.5°C and 65% ± 5% humidity. Histopathology, ATR-FTIR spectroscopy, and machine learning identified the hypothalamus, hippocampus, liver, and spleen as the most affected organs. Transcriptomic (UID mRNA-seq) and proteomic (DIA) analyses of the hypothalamus revealed 447 differentially expressed genes and 692 differentially expressed proteins. Integrated multi-omics analysis highlighted pathways including endoplasmic reticulum protein processing, MAPK signaling, and apoptosis. Three key genes/proteins (Hspb1, Dnaja1, Jun) were validated by qRT-PCR, Western blot, and immunohistochemistry. This study provides new insights into HS diagnosis and mechanisms, offering scientific evidence for forensic and clinical applications. |
| HostingRepository | iProX |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-25_20:02:41.543.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hongli Xiong |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-25 20:00:46 | ID requested | |
| ⏵ 1 | 2026-05-25 20:02:42 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: heatstroke, ATR-FTIR, Machine learning, multi-omics analysis |
Contact List
| Jianbo Li | |
|---|---|
| contact affiliation | Chongqing Medical University |
| contact email | 100390@cqmu.edu.cn |
| lab head | |
| Hongli Xiong | |
| contact affiliation | Chongqing Medical University |
| contact email | 15023159916@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
