PXD078804

PXD078804 is an original dataset announced via ProteomeXchange.

Title	Screening syringin targets by limited proteolysis-coupled mass spectrometry (LIP-MS)
Description	Gastrointestinal diseases and disorders (GIDD) are often comorbid with mental disorders, including depression, anxiety, cognitive impairment and so on. Repairing intestinal mucosal injury is an effective strategy to prevent exogenous substances from entering the blood circulation, thus mitigating neuroinflammation and subsequent psychiatric symptoms. Our study revealed that syringin, an active ingredient derived from traditional Chinese medicine, can markedly alleviate intestinal barrier damage induced by radiation, chemotherapeutic agents and dextran sulfate sodium (DSS), as well as intestinal injury-related cognitive deficits and anxiety-like behaviors. To further explore the potential targets responsible for its intestinal protective effects, we performed target screening via limited proteolysis-coupled mass spectrometry (LIP-MS).
HostingRepository	iProX
AnnounceDate	2026-05-25
AnnouncementXML	Submission_2026-09-03_17:05:37.173.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zebin Liao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-25 01:51:41	ID requested
⏵ 1	2026-09-03 17:05:37	announced

Dataset with its publication pending

submitter keyword: intestinal cell, syringin, LIP-MS

Yue Gao
contact affiliation	Academy of Military Medical Sciences
contact email	gaoyue@bmi.ac.cn
lab head
Zebin Liao
contact affiliation	Academy of Military Medical Sciences
contact email	18701832213@163.com
dataset submitter

iProX dataset URI