⮝ Full datasets listing
PXD078794
PXD078794 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Hos2-mediated KatG1 decrotonylation orchestrates ROS scavenging in rice blast infection |
| Description | In plant–pathogen interaction, plants trigger reactive oxygen species (ROS) bursts to defend against pathogen invasion, while pathogens evolved antioxidant systems to scavenge ROS for infection. Our study reveals a novel regulatory mechanism of ROS adaptation and scavenging in the rice blast fungus Magnaporthe oryzae. We found that KatG1, a bifunctional catalase-peroxidase, acts as a ROS-responsive regulatory enzyme. During infection, the deacetylase Hos2 mediates the decrotonylation of KatG1 at K422, initiating the ROS clearance process. Decrotonylated KatG1 depolymerizes into monomers, interacts with the Hsp70 protein Ssb1, and translocates to the nucleus. Nuclear KatG1 promotes the dissociation of the Atf1-Tup1 complex, activating the expression of Atf1-mediated oxidoreductase genes and enhancing fungal infection. Moreover, we identified a small molecule, orcinol gentiobioside (OGB), that targets KatG1, inhibiting M. oryzae invasion. This study elucidates a new regulatory mechanism of ROS metabolism and stress adaptation in plant fungal infections and provides a potential target for fungicide development to control rice blast disease |
| HostingRepository | iProX |
| AnnounceDate | 2026-05-23 |
| AnnouncementXML | Submission_2026-05-25_01:28:40.790.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiyong Ren |
| SpeciesList | scientific name: Pyricularia oryzae 70-15; NCBI TaxID: 242507; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-25 01:26:58 | ID requested | |
| ⏵ 1 | 2026-05-25 01:28:41 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Magnaporthe oryzae, KatG1, Decrotonylation, ROS scavenging, Infection mechanism |
Contact List
| Xiaolin Chen | |
|---|---|
| contact affiliation | Huazhong Agricultural University |
| contact email | chenxiaolin@mail.hzau.edu.cn |
| lab head | |
| Zhiyong Ren | |
| contact affiliation | Huazhong Agricultural University |
| contact email | 1402515252@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
