PXD078790

PXD078790 is an original dataset announced via ProteomeXchange.

Title	Study on Lipid Analysis of Meibomian Gland lipids with Different Degrees of Meibomian Dysfunction
Description	Meibomian gland dysfunction (MGD) is a leading cause of dry eye disease, yet the underlying lipid metabolic alterations remain poorly understood due to the limited lipid content of meibomian secretions. In this study, we employed LC-MS-based non-targeted lipidomics to comprehensively profile the lipidome of meibum samples from 670 participants, including non-MGD controls and patients with mild, moderate, and severe MGD. Our analysis identified 4,235 lipids across 40 subclasses, revealing significant shifts in lipid composition with disease progression—most notably, increases in wax esters and ceramides, and decreases in diacylglycerols and hexosylceramides.
HostingRepository	iProX
AnnounceDate	2026-05-23
AnnouncementXML	Submission_2026-05-25_01:14:23.455.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Li Chen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-25 01:14:08	ID requested
⏵ 1	2026-05-25 01:14:24	announced

Dataset with its publication pending

submitter keyword: Meibomian gland dysfunction (MGD), Non-targeted lipidomics, Glycerophospholipid metabolism pathway

Yihui Chen
contact affiliation	School of Medicine, Tongji University
contact email	1300089@tongji.edu.cn
lab head
Li Chen
contact affiliation	School of Medicine, Tongji University
contact email	2280297@tongji.edu.cn
dataset submitter

iProX dataset URI