⮝ Full datasets listing
PXD078789
PXD078789 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Development of Dual-Mechanism Small-Molecule Degraders for Treatment of Advanced Prostate Cancer |
| Description | In this study, we present the discovery, mechanistic insights, and preclinical validation of a potent, selective small-molecule drug candidate with dual PROTAC and molecular glue mechanisms that target human androgen receptors. This drug lead shows remarkable therapeutic potential on various drug-resistant prostate cancers. |
| HostingRepository | iProX |
| AnnounceDate | 2026-05-23 |
| AnnouncementXML | Submission_2026-05-25_01:13:09.755.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Peiqi Chen |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | artifact |
| Instrument | TripleTOF 6600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-25 01:12:49 | ID requested | |
| ⏵ 1 | 2026-05-25 01:13:10 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: androgen receptor, castration-resistant prostate cancer, protein degradation, PROTAC, AR-V7, proteomics |
Contact List
| Xiaoguang Lei | |
|---|---|
| contact affiliation | Peking University |
| contact email | xglei@pku.edu.cn |
| lab head | |
| Peiqi Chen | |
| contact affiliation | Shenzhen Bay Laboratory |
| contact email | 15101218211@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
