PXD078788

PXD078788 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of extracellular vesicles (EVs) isolated from peritoneal dialysis effluent (PDE) of short-term (SPD) and long-term (LPD) PD patients
Description	This project presents proteomic profiling of extracellular vesicles (EVs) isolated from peritoneal dialysis effluent (PDE) of short-term (SPD) and long-term (LPD) PD patients. We identified 536 differentially expressed proteins (DEPs), revealing an immune-enriched EV signature in LPD. CSF1 was prioritized as a key profibrotic mediator, validated in vitro and in vivo to drive macrophage-to-myofibroblast transition (MMT) via AKT signaling. Clinical data (n=84) links dialysate CSF1 to PF progression. This dataset provides mechanistic insights and biomarker candidates for PD-related fibrosis.
HostingRepository	iProX
AnnounceDate	2026-05-23
AnnouncementXML	Submission_2026-05-25_01:10:24.266.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaocui Chen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-25 01:10:06	ID requested
⏵ 1	2026-05-25 01:10:24	announced

Dataset with its publication pending

submitter keyword: Proteomic ,extracellular vesicles ,peritoneal dialysis

Pei Zhang
contact affiliation	Department of Nephrology, The First Affiliated Hospital of Anhui Medical University
contact email	zhangpei@ahmu.edu.cn
lab head
Xiaocui Chen
contact affiliation	Guangzhou National Laboratory
contact email	raoqingqingrqq@126.com
dataset submitter

iProX dataset URI